Postdoctoral Scientist

Dr Katy Moffat

Group

Porcine Reproductive and Respiratory Syndrome (PRRS) Immunology

Expertise

Bioimaging, Cell Biology, Immunology

Dr Katy Moffat

Group

Porcine Reproductive and Respiratory Syndrome (PRRS) Immunology

Katy Moffat studied for her BSc Hons in Biochemistry at Stirling University and then completed her PhD at the John Innes centre, studying the effects of gene silencing on virus infection in plants. She joined the Immunology group at The Pirbright Institute in 2001 to examine interactions between foot-and-mouth disease virus (FMDV) and intracellular proteins during virus replication.

Katy discovered that FMDV infection lead to a disruption of the cellular protein secretory pathway and the viral protein responsible differed to that of another picornavirus, Poliovirus. In 2006, Katy became part of the Vaccinology group and is currently studying responses of dendritic cells (immune cells) to bluetongue virus (BTV) infection.

Publications

Rathakrishnan A, Connell S, Petrovan V, Moffat K, Goatley L C, Jabbar T, Sanchez-Cordon P J, Reis A L, Dixon L K (2022)

Differential effect of deleting members of African swine fever virus multigene families 360 and 505 from the genotype II Georgia 2007/1 isolate on virus replication, virulence and induction of protection

Journal Journal of Virology

Read abstract

Childs K, Juleff N, Moffat K, Seago J (2021)

Demonstration of co-infection and trans-encapsidation of viral RNA in vitro using epitope-tagged foot-and-mouth disease viruses.

Journal Viruses

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Petrovan V, Rathakrishnan A, Islam M, Goatley L C, Moffat K, Sanchez-Cordon P J, Reis A L, Dixon L K (2022)

Role of African swine fever virus (ASFV) proteins EP153R and EP402R in reducing viral persistence in blood and virulence in pigs infected with BeninΔDP148R

Journal Journal of Virology

Read abstract

Roy P, Moffat K, Nair V, Yao Y (2021)

CRISPR-mediated gene activation (CRISPRa) of pp38/pp24 orchestrates events triggering lytic infection in Marekâs disease virus-transformed cell lines

Journal Microorganisms

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Rathakrishnan A, Reis A L, Goatley L C, Moffat K, Dixon L K (2021)

Deletion of the K145R and DP148R genes from the virulent ASFV Georgia 2007/1 isolate delays the onset, but does not reduce severity, of clinical signs in infected pigs

Journal Viruses

Read abstract

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Articles

A diagram showing how a yellow tetramer with a green virus segment attached to each of its four arms is able to be recognised by a blue T cell.

17 June 2021

Pirbright scientists use ‘molecular magnets’ to discover FMD virus segments that could improve vaccine effectiveness

Recent research from The Pirbright Institute has revealed new parts of the foot-and-mouth disease virus (FMDV) that stimulate an immune response, which could be used to inform the design of improved vaccines. They also discovered that specific immune cells were present in cattle samples four years…

A pig in straw in the high containment animal facilities at The Pirbright Institute

04 March 2021

Pirbright generates first pig flu antibodies that could improve human treatments and guide flu vaccine selection

The Pirbright Institute has generated the first pig antibodies against swine influenza (flu) that protect against infection and recognise the same parts of the flu virus as human antibodies. This indicates they could be used to develop and assess human antibody therapies and their delivery methods…

22 January 2021

Early animal studies by Pirbright and Oxford yield promising results for new potential COVID-19 vaccine

Studies carried out by The Pirbright Institute and the University of Oxford have shown that Oxford’s new potential vaccine against COVID-19, named RBD-SpyVLP, produces a strong antibody response in mice and pigs, providing vital information for the further development of the vaccine. Although this…

graphic representation of the coronavirus

08 January 2021

Pirbright study shows how SARS-CoV-2 could have adapted from bats to humans and which other animals it could infect

Severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2), the virus that causes COVID-19, is thought to have originated in bats, but how it jumped hosts to infect humans is unclear, as is the potential for the virus to infect other animal species. Researchers from The Pirbright Institute have…

23 June 2020

Studies at Pirbright demonstrate two doses of Oxford University’s COVID-19 vaccine boosts immune response in pigs

The Pirbright Institute, working in collaboration with the University of Oxford, have successfully shown that two doses of the ChAdOx1 nCoV-19 (AZD1222) vaccine produce a greater antibody response than a single dose in pigs. The emergence and subsequent spread of SARS-CoV-2 has caused a global…

08 January 2019

Pirbright scientists share new protocol for creating vaccines that target multiple poultry diseases

Researchers at The Pirbright Institute have published their methods for creating a vaccine that protects against Marek’s disease and infectious bursal disease (IBD) using CRISPR/Cas9 gene editing system in the video journal JoVE. Both viruses cause highly infectious diseases of poultry and cause…

22 October 2018

Pirbright scientists show two peste des petits ruminants vaccines protect against all strains

Scientists at The Pirbright Institute have conducted the first study to directly compare the ability of two peste des petits ruminants (PPR) vaccines to protect susceptible animals against wildtype viruses from any of the four genetic lineages of PPR virus. Through analysing the immune response of…

22 January 2018

New vaccine technique targets multiple poultry diseases

Researchers at The Pirbright Institute have created a new method of genetically modifying the Marek’s disease vaccine so that it is able to protect against another destructive poultry virus called infectious bursal disease (IBD), and potentially others such as avian influenza and Newcastle disease…

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Dr Katy Moffat

Publications

Differential effect of deleting members of African swine fever virus multigene families 360 and 505 from the genotype II Georgia 2007/1 isolate on virus replication, virulence and induction of protection

Demonstration of co-infection and trans-encapsidation of viral RNA in vitro using epitope-tagged foot-and-mouth disease viruses.

Role of African swine fever virus (ASFV) proteins EP153R and EP402R in reducing viral persistence in blood and virulence in pigs infected with BeninΔDP148R

CRISPR-mediated gene activation (CRISPRa) of pp38/pp24 orchestrates events triggering lytic infection in Marekâs disease virus-transformed cell lines

Deletion of the K145R and DP148R genes from the virulent ASFV Georgia 2007/1 isolate delays the onset, but does not reduce severity, of clinical signs in infected pigs

Articles

Pirbright scientists use ‘molecular magnets’ to discover FMD virus segments that could improve vaccine effectiveness

Pirbright generates first pig flu antibodies that could improve human treatments and guide flu vaccine selection

Early animal studies by Pirbright and Oxford yield promising results for new potential COVID-19 vaccine

Pirbright study shows how SARS-CoV-2 could have adapted from bats to humans and which other animals it could infect

Studies at Pirbright demonstrate two doses of Oxford University’s COVID-19 vaccine boosts immune response in pigs

Pirbright scientists share new protocol for creating vaccines that target multiple poultry diseases

Pirbright scientists show two peste des petits ruminants vaccines protect against all strains

New vaccine technique targets multiple poultry diseases

Contact

CRISPR-mediated gene activation (CRISPRa) of pp38/pp24 orchestrates events triggering lytic infection in Marekâs disease virus-transformed cell lines