Scientist Dr Graham Freimanis Group Bioinformatics, Sequencing & Proteomics Expertise Epidemiology, Molecular Biology, Virology Dr Graham Freimanis Group Bioinformatics, Sequencing & Proteomics Projects Pathogenesis, immunity, and control of coronaviruses in a large natural host animal, the pig Understanding porcine coronaviruses to safeguard human and livestock health. Publications Chrun, T, Maze, EA, Roper, KJ, Vatzia, E, Paudyal, B, McNee, A, Martini, V, Manjegowda, T, Freimanis, G, Silesian, A, Polo, N, Clark, B, Besell, E, Booth, G, Carr, BV, Edmans, M, Nunez, A, Koonpaew, S, Wanasen, N, Graham, SP, Tchilian, E (2023) Simultaneous co-infection with swine influenza A and porcine reproductive and respiratory syndrome viruses potentiates adaptive immune responses Journal Frontiers in Immunology Read abstract Keep S, Dowgier G, Lulla V, Britton P, Oade M, Freimanis G, Tennakoon C, Jonassen CM, Tengs T, Bickerton E (2023) Deletion of the s2m RNA Structure in the Avian Coronavirus Infectious Bronchitis Virus and Human Astrovirus Results in Sequence Insertions Journal Journal of Virology Read abstract King D J, Freimanis G, Neil C, Shaw A, Tuthill T J, Laing E, King D P, Lasecka-Dykes L (2022) Establishing an in vitro system to assess how specific antibodies drive the evolution of foot-and-mouth disease virus Journal Viruses Read abstract Webb I, Keep S, Littolff K, Stuart J, Freimanis G, Britton P, Davidson A D, Maier H J, Bickerton E (2022) The genetic stability, replication kinetics and cytopathogenicity of recombinant avian coronaviruses with a T16A or an A26F mutation within the E protein is cell-type dependent Journal Viruses Read abstract Chrzastek K, Tennakoon C, Bialy D, Freimanis G, Flannery J, Shelton H (2022) A random priming amplification method for whole genome sequencing of SARS-CoV-2 virus Journal BMC Genomics Read abstract Pagination Previous page Previous Page 1 Page 2 Page 3 Page 4 Page 5 Page 6 Next page Next Articles 19 September 2024 Pirbright researchers map genome of inbred pig model Scientists at The Pirbright Institute have generated a nearly complete genome assembly for an inbred domestic pig breed, enhancing the animal’s potential use as a biomedical model for better human and animal health. Derived from the domestic Large White pig breed, the highly inbred Babraham pig is… Read more 10 March 2022 Pirbright develops new ways to create safe vaccines to protect poultry from infectious bronchitis virus Researchers from The Pirbright Institute working to improve vaccines for infectious bronchitis virus (IBV) have identified targets in the virus’s genetic code that could make vaccines safer. Better vaccines would have a huge impact on improving health and welfare of poultry and protect food security… Read more 24 August 2020 Pirbright scientists contribute to new coronavirus book Pirbright scientists have edited and authored chapters in a new book titled ‘Coronaviruses’ which provides detailed information about the Coronaviridae family as well as laboratory techniques currently used in the field to study them. Whilst coronaviruses have long been known to cause devasting… Read more 04 August 2020 Pirbright scientists identify new genes in infectious bronchitis virus Two new genes have been identified in infectious bronchitis virus (IBV), a coronavirus that causes an acute, highly contagious and economically important respiratory disease of poultry. The research, carried out by scientists at The Pirbright Institute, raises the prospect that coronavirus genomes… Read more 29 May 2019 Persistently infected African buffalo not a likely cause of new FMD outbreaks say Pirbright scientists Scientists at The Pirbright Institute have shown that African buffalo persistently infected with foot-and-mouth disease (FMD) are unlikely to be the source of new outbreaks in other buffalo and cattle. African buffalo do not usually present any clinical signs of infection and can carry FMD for years… Read more 15 May 2019 Pirbright scientists identify mutation hotspots that may inform infectious bronchitis vaccine development Scientists at The Pirbright Institute have shown that infectious bronchitis virus (IBV) vaccines produced in eggs have unpredictable mutations which may be prone to reversion in the field. IBV causes a poultry disease which results in large economic losses across the globe. Live attenuated vaccines… Read more Contact Title Message Submit message
Pathogenesis, immunity, and control of coronaviruses in a large natural host animal, the pig Understanding porcine coronaviruses to safeguard human and livestock health.
Chrun, T, Maze, EA, Roper, KJ, Vatzia, E, Paudyal, B, McNee, A, Martini, V, Manjegowda, T, Freimanis, G, Silesian, A, Polo, N, Clark, B, Besell, E, Booth, G, Carr, BV, Edmans, M, Nunez, A, Koonpaew, S, Wanasen, N, Graham, SP, Tchilian, E (2023) Simultaneous co-infection with swine influenza A and porcine reproductive and respiratory syndrome viruses potentiates adaptive immune responses Journal Frontiers in Immunology Read abstract
Keep S, Dowgier G, Lulla V, Britton P, Oade M, Freimanis G, Tennakoon C, Jonassen CM, Tengs T, Bickerton E (2023) Deletion of the s2m RNA Structure in the Avian Coronavirus Infectious Bronchitis Virus and Human Astrovirus Results in Sequence Insertions Journal Journal of Virology Read abstract
King D J, Freimanis G, Neil C, Shaw A, Tuthill T J, Laing E, King D P, Lasecka-Dykes L (2022) Establishing an in vitro system to assess how specific antibodies drive the evolution of foot-and-mouth disease virus Journal Viruses Read abstract
Webb I, Keep S, Littolff K, Stuart J, Freimanis G, Britton P, Davidson A D, Maier H J, Bickerton E (2022) The genetic stability, replication kinetics and cytopathogenicity of recombinant avian coronaviruses with a T16A or an A26F mutation within the E protein is cell-type dependent Journal Viruses Read abstract
Chrzastek K, Tennakoon C, Bialy D, Freimanis G, Flannery J, Shelton H (2022) A random priming amplification method for whole genome sequencing of SARS-CoV-2 virus Journal BMC Genomics Read abstract
19 September 2024 Pirbright researchers map genome of inbred pig model Scientists at The Pirbright Institute have generated a nearly complete genome assembly for an inbred domestic pig breed, enhancing the animal’s potential use as a biomedical model for better human and animal health. Derived from the domestic Large White pig breed, the highly inbred Babraham pig is… Read more
10 March 2022 Pirbright develops new ways to create safe vaccines to protect poultry from infectious bronchitis virus Researchers from The Pirbright Institute working to improve vaccines for infectious bronchitis virus (IBV) have identified targets in the virus’s genetic code that could make vaccines safer. Better vaccines would have a huge impact on improving health and welfare of poultry and protect food security… Read more
24 August 2020 Pirbright scientists contribute to new coronavirus book Pirbright scientists have edited and authored chapters in a new book titled ‘Coronaviruses’ which provides detailed information about the Coronaviridae family as well as laboratory techniques currently used in the field to study them. Whilst coronaviruses have long been known to cause devasting… Read more
04 August 2020 Pirbright scientists identify new genes in infectious bronchitis virus Two new genes have been identified in infectious bronchitis virus (IBV), a coronavirus that causes an acute, highly contagious and economically important respiratory disease of poultry. The research, carried out by scientists at The Pirbright Institute, raises the prospect that coronavirus genomes… Read more
29 May 2019 Persistently infected African buffalo not a likely cause of new FMD outbreaks say Pirbright scientists Scientists at The Pirbright Institute have shown that African buffalo persistently infected with foot-and-mouth disease (FMD) are unlikely to be the source of new outbreaks in other buffalo and cattle. African buffalo do not usually present any clinical signs of infection and can carry FMD for years… Read more
15 May 2019 Pirbright scientists identify mutation hotspots that may inform infectious bronchitis vaccine development Scientists at The Pirbright Institute have shown that infectious bronchitis virus (IBV) vaccines produced in eggs have unpredictable mutations which may be prone to reversion in the field. IBV causes a poultry disease which results in large economic losses across the globe. Live attenuated vaccines… Read more
![african buffalo - needs credit: Haplochromis [CC BY-SA 3.0 (httpscreativecommons.orglicensesby-sa3.0)]](/sites/default/files/styles/max_325x325/public/quick_media/NS19022_African-buffalo-%28Syncerus_caffer%29-Wiki-commons---Credit---Haplochromis-%5BCC-BY-SA-3.0-%28httpscreativecommons.jpg?itok=Hybgde4Y "african buffalo")
