Dr John Schwartz

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Immunogenetics

John Schwartz’s research focuses on characterising the genomic diversity of immune genes. He obtained his PhD in 2013 from the University of Minnesota where he studied the porcine B-cell repertoire.

His current work involves characterising the organisation, evolution, and the diversity of genes which encode immune cell receptors in mammalian species. These include genes of the major histocompatibility complex (MHC), leukocyte receptor complex (LRC), natural killer complex (NKC), the B-cell and T-cell receptor loci, and Fc receptors. He is interested in the application of this knowledge in identifying the genetic bases of disease resistance, and ultimately to inform livestock breeding programmes for the development of disease-resistant animals.

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Dr John Schwartz

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Dr John Schwartz

Publications

A genome assembly and transcriptome atlas of the inbred Babraham pig to illuminate porcine immunogenetic variation

Distinct effector functions mediated by Fc regions of bovine IgG subclasses and their interaction with Fc gamma receptors

A Customizable Suite of Methods to Sequence and Annotate Cattle Antibodies

Fc-mediated functions of porcine IgG subclasses

Highly-contiguous bovine genomes underpin accurate functional analyses and updated nomenclature of MHC class I

Articles

Pirbright researchers map genome of inbred pig model

Pirbright generates first pig flu antibodies that could improve human treatments and guide flu vaccine selection

Pirbright scientists uncover goat immune genes involved in natural resistance

Pig immunology comes of age: killer T cell responses to influenza

Position and function of goat antibody genes identified at Pirbright

Technique used to generate new goat genome assembly sets the standard for future projects.

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