Senior Postdoctoral Scientist

Dr John Schwartz

Group

Immunogenetics

Expertise

Bioinformatics, Genetics, Genomics, Immunology

Dr John Schwartz

Group

Immunogenetics

John Schwartz’s research focuses on characterising the genomic diversity of immune genes. He obtained his PhD in 2013 from the University of Minnesota where he studied the porcine B-cell repertoire.

His current work involves characterising the organisation, evolution, and the diversity of genes which encode immune cell receptors in mammalian species. These include genes of the major histocompatibility complex (MHC), leukocyte receptor complex (LRC), natural killer complex (NKC), the B-cell and T-cell receptor loci, and Fc receptors. He is interested in the application of this knowledge in identifying the genetic bases of disease resistance, and ultimately to inform livestock breeding programmes for the development of disease-resistant animals.

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Publications

Noble A, Paudyal B, Schwartz JC, Mwangi W, Munir D, Tchilian E, Hammond JA, Graham SP (2023)

Distinct effector functions mediated by Fc regions of bovine IgG subclasses and their interaction with Fc gamma receptors

Journal Frontiers in Immunology

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Valdez KR, Nzau B, Dorey-Robinson D, Jarman M, Nyagwange J, Schwartz JC, Freimanis G, Steyn AW, Warimwe GM, Morrison LJ, Mwangi W, Charleston B, Bonnet-Di Placido M, Hammond JA (2023)

A Customizable Suite of Methods to Sequence and Annotate Cattle Antibodies

Journal vaccines

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Paudyal B, Mwangi W, Rijal P, Schwartz J C, Noble A, Shaw A, Sealy J E, Bonnet-Di Placido M, Graham S P, Townsend A, Hammond J A, Tchilian E (2022)

Fc-mediated functions of porcine IgG subclasses

Journal Frontiers in Immunology

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Schwartz J C, Maccari G, Heimeier D, Hammond J A (2022)

Highly-contiguous bovine genomes underpin accurate functional analyses and updated nomenclature of MHC class I

Journal HLA

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Le Page L, Gillespie A, Schwartz J C, Prawits L-M, Schlerka A, Farrell C P, Hammond J A, Baldwin C, Telfer J, Hammer S E (2021)

Subpopulations of swine γδ T cells defined by TCRγ and WC1 gene expression

Journal Developmental and Comparative Immunology

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Articles

Small light pink pig with yellow tag in ear

19 September 2024

Pirbright researchers map genome of inbred pig model

Scientists at The Pirbright Institute have generated a nearly complete genome assembly for an inbred domestic pig breed, enhancing the animal’s potential use as a biomedical model for better human and animal health. Derived from the domestic Large White pig breed, the highly inbred Babraham pig is…

A pig in straw in the high containment animal facilities at The Pirbright Institute

04 March 2021

Pirbright generates first pig flu antibodies that could improve human treatments and guide flu vaccine selection

The Pirbright Institute has generated the first pig antibodies against swine influenza (flu) that protect against infection and recognise the same parts of the flu virus as human antibodies. This indicates they could be used to develop and assess human antibody therapies and their delivery methods…

09 October 2019

Technique used to generate new goat genome assembly sets the standard for future projects.

An international scientific collaboration, including expert geneticists from The Pirbright Institute, has generated a new goat genome assembly which is the most complete produced for any mammal to date. By using a combination of techniques in parallel, the approach could revolutionise the process of…

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Dr John Schwartz

Publications

Distinct effector functions mediated by Fc regions of bovine IgG subclasses and their interaction with Fc gamma receptors

A Customizable Suite of Methods to Sequence and Annotate Cattle Antibodies

Fc-mediated functions of porcine IgG subclasses

Highly-contiguous bovine genomes underpin accurate functional analyses and updated nomenclature of MHC class I

Subpopulations of swine γδ T cells defined by TCRγ and WC1 gene expression

Articles

Pirbright researchers map genome of inbred pig model

Pirbright generates first pig flu antibodies that could improve human treatments and guide flu vaccine selection

Pirbright scientists uncover goat immune genes involved in natural resistance

Pig immunology comes of age: killer T cell responses to influenza

Position and function of goat antibody genes identified at Pirbright

Technique used to generate new goat genome assembly sets the standard for future projects.

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