The X proteins of bornaviruses interfere with type I interferon signalling

Borna disease virus (BDV) is a neurotropic, negative-stranded RNA virus causing persistent infection and progressive neurological disorders in a wide range of warm-blooded animals. The role of the small non-structural X protein in viral pathogenesis is not completely understood. Here we investigated whether the X protein of BDV and avian bornavirus (ABV) interferes with the type I interferon (IFN) system, similar to other non-structural proteins of negative-stranded RNA viruses. In luciferase reporter assays, we found that the X protein of various bornaviruses interfered with the type I IFN system at all checkpoints investigated, in contrast to previously reported findings, resulting in reduced type I IFN secretion.
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Publication
Contributors
Wensman J J, Munir M, Thaduri S, Hornaeus K, Rizwan M, Blomstrom A-L, Briese T, Lipkin W I, Berg M
Year
2013
Journal
Journal of General Virology
Volume
94
Pages
263-269
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