Recombinant VP4 of human rhinovirus induces permeability in model membranes

In common with all nonenveloped viruses, the mechanism of picornavirus membrane penetration during cell entry is poorly understood. The small, myristylated capsid protein VP4 has been implicated in this process. Here we show that recombinant VP4 of human rhinovirus 16 has the ability to associate with and induce membrane permeability in otherwise intact liposomes. This provides further evidence that VP4 plays a key role in picornavirus cell entry.
Back to publications
Publication
Contributors
Davis M P, Bottley G, Beales L P, Killington R A, Rowlands D J, Tuthill T J
Year
2008
Journal
Journal of Virology
Volume
82
Issue
8
Pages
4169-4174
Altmetric details