A point mutation in CD45 may be associated with an increased risk of HIV-1 infection

The CD45 antigen is essential for normal antigen receptor-mediated signalling in lymphocytes, and different patterns of splicing of CD45 are associated with distinct functions in lymphocytes. Here we show that abnormal CD45 splicing caused by a C77G transversion in exon A of the gene encoding CD45 (PTPRC) is associated with increased susceptibility to HIV-1 infection.
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Publication
Contributors
Tchilian E Z, Wallace D L, Dawes R, Imami N, Burton C, Gotch F, Beverley P C L
Year
2001
Journal
AIDS
Volume
15
Issue
14
Pages
1892-1894
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