Modelling the influence of foot-and-mouth disease vaccine antigen stability and dose on the bovine immune response

Foot and mouth disease virus causes a livestock disease of significant global socio-economic importance. Advances in its control and eradication depend critically on improvements in vaccine efficacy, which can be best achieved by better understanding the complex within-host immunodynamic response to inoculation. We present a detailed and empirically parametrised dynamical mathematical model of the hypothesised immune response in cattle, and explore its behaviour with reference to a variety of experimental observations relating to foot and mouth immunology. The model system is able to qualitatively account for the observed responses during in-vivo experiments, and we use it to gain insight into the incompletely understood effect of single and repeat inoculations of differing dosage using vaccine formulations of different structural stability.

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Publication
Contributors
Schley D, Tanaka R J, Leungchavaphongse K, Shahrezaei V, Ward J, Grant C, Charleston B, Rhodes C J
Year
2012
Journal
PLoS ONE
Volume
7
Issue
2
Pages
e30435
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