Actin-based motility of Burkholderia thailandensis requires a central acidic domain of BimA that recruits and activates the cellular Arp2/3 complex
Burkholderia species use BimA for intracellular actin-based motility. Uniquely, Burkholderia thailandensis BimA harbors a central and acidic (CA) domain. The CA domain was required for actin-based motility, binding to the cellular Arp2/3 complex, and Arp2/3-dependent polymerization of actin monomers. Our data reveal distinct strategies for actin-based motility among Burkholderia species.
Back to publications
Publication
Contributors
Sitthidet C, Stevens J M, Field T R, Layton A N, Korbsrisate S, Stevens M P
Year
2010
Journal
Journal of Bacteriology
Volume
192
Issue
19
Pages
5249-5252
Altmetric details