Research Assistant

The Pirbright Institute delivers world-leading research to understand, predict, detect and respond to viral disease outbreaks. We study viruses of livestock that are endemic and exotic to the UK, including zoonotic viruses, by using the most advanced tools and technologies to understand host-pathogen interactions in animals and arthropod vectors. Our major strength in understanding the immune systems of livestock provides a platform to control current diseases and respond to emerging threats. 

Our Institute is made up of a dynamic and vibrant community of staff covering a diverse set of chosen fields, backgrounds and experience. We all play a crucial role in furthering the Institute’s aspirations, advancing the frontiers of science and knowledge through our excellent scientific research, knowledge sharing and contribution; with a real focus in improving the world in which we live. Our outlook is always balanced by our strong sense of purpose, values and behaviours and an unwavering commitment to a ‘one Institute’ approach.

Organisation position and purpose

We are looking for a talented and motivated scientist to join our Mucosal Immunology group, contributing to groundbreaking research on broadly cross-reactive influenza vaccines. This role is funded by the BBSRC, Gates Foundation, and FluLab as part of a major strategic initiative.

You will play a key role in developing viral-vectored vaccines designed to protect against influenza, including potential pandemics. Our research focuses on evaluating vaccine efficacy in pigs - a model closely resembling human influenza exposure. By studying immune responses across multiple tissues, we aim to understand how different vaccination routes impact protection.

In addition to vaccine development, you will contribute to a Gates Foundation-funded project investigating novel therapeutics that could block influenza transmission.

We welcome applications from virologists and immunologists with a strong interest in translational research for human and animal health. The ideal candidate will have experience in immunological and virological techniques and an enthusiasm for collaborative, One Health-focused research.

This is an exciting opportunity to be part of a world-class consortium working at the cutting edge of vaccine and therapeutic development.

You will report to the Mucosal Immunology Group Leader.

Main duties and responsibilities:

Responsible for conducting research into transmission, evolution and immunity to swine influenza viruses:

• Preparation of virus challenge material and quantification of virus load in tissues. 
• Mammalian expression of protein antigens.
• Analysis of T cell responses after influenza infection and/or immunisation (ELISPOT, Flow cytometry).
• Assay of antibody responses (microneutralisation, ELISA, HAI, epitope mapping, ADCC).
• Contribute to animal studies to evaluate properties of transmission blockers.

                                             
Responsible for working as part of a research team, which will include: 

• Communicating progress and data, including presentations at internal and external meetings 
• Preparation of manuscripts for peer-review, stage-based milestone reviews and end of programme assessments
• Developing and maintaining documentation associated with the health, safety and biosecurity of the research to preserve a safe working environment. 
• Assist with lab management (ordering, looking after equipment, sample inventories) 
• Perform outreach duties.

Due to the nature of the work we do, all successful applicants will be required to go through a comprehensive screening process including reference and qualification checks, financial and security clearances. 

Essential/Desirable requirements

Essential

• Relevant Life science degree as a minimum (MSc, Master or higher) in Molecular Biology, Virology, Immunology or other science related field 
• Evidence of good oral and written communication skills including the ability to communicate effectively within a team 
• Previous experience in immunology and/or virology research 
• Must be able to give meticulous attention to detail including the management of samples and recording of data

Desirable

• Experience of flow cytometry and other immunological or molecular biology techniques 
• Experience of working in a laboratory environment 
• Evidence of networking skills with the ability to build effective collaborative relationships
• Computer literate with a good knowledge of different computer programs and experience in data presentation

What we offer

• Generous Group Personal Pension Scheme and life cover (subject to age and earnings)
• 25 days annual leave per annum, pro rata, plus 10.5 public and privilege days
• Buy and sell annual leave 
• Option to carry over up to two weeks annual leave
• Pirbright gym with subsidised membership 
• Pirbright social club
• Pirbright Lifestyle Hub (employee discount site) 
• Cycle to work 
• Subsidised employee restaurant
• Childcare allowance
• Free onsite parking 
• Electric car charging facilities 

Due to the high volume of applications we receive, if you have not heard from us within one month from closing date of the vacancy, then please contact us on jobs@pirbright.ac.uk for an update.