Postdoctoral Scientist

The Pirbright Institute delivers world-leading research to understand, predict, detect and respond to viral disease outbreaks. We study viruses of livestock that are endemic and exotic to the UK, including zoonotic viruses, by using the most advanced tools and technologies to understand host-pathogen interactions in animals and arthropod vectors. Our major strength in understanding the immune systems of livestock provides a platform to control current diseases and respond to emerging threats.

Our Institute is made up of a dynamic and vibrant community of staff covering a diverse set of chosen fields, backgrounds and experience. We all play a crucial role in furthering the Institute’s aspirations, advancing the frontiers of science and knowledge through our excellent scientific research, knowledge sharing and contribution; with a real focus in improving the world in which we live. Our outlook is always balanced by our strong sense of purpose, values and behaviours and an unwavering commitment to a ‘one Institute’ approach.

Organisation and purpose

We are seeking a highly motivated Postdoctoral Scientist to join a collaborative project between The Pirbright Institute and The Moredun Research Institute, funded by the Bill & Melinda Gates Foundation.

The project aims to develop novel vaccines against Haemonchus contortus, a major parasitic threat to small ruminants worldwide, which has a significant economic impact on global livestock industries. The primary objective is to generate a library of functionally-relevant sheep monoclonal antibodies (mAbs) against H. contortus to inform vaccine development and selection.

The Postdoctoral Scientist will work within the Immunogenetics and Immunological Toolbox Groups, applying cutting-edge antibody discovery techniques, including single-cell antibody sequencing, spectral flow cytometry, and high-throughput antibody expression systems. The role offers an exciting opportunity to contribute directly to vaccine research by characterising H. contortus-specific mAbs and advancing our understanding of host-parasite interactions.

Main duties and responsibilities:

Designing, performing, and analysing experiments (80%)

• Design and execute experiments to isolate H. contortus (H-gal-GP complex antigen) specific mAbs from sheep using single B cell discovery technologies. (30%)
• Recombinant expression and purification of sheep monoclonal antibodies (IgGs isotypes) using a mammalian expression system. (20%)
• Develop assays to characterise antibody binding and function. (20%)
• Analyse experimental data using appropriate statistical and analytical tools. (10%)
   

Responsible for the laboratory activities of the Immunological Toolbox, which will include (20%):

• Provide support to other members of the team as required, including assisting with their experiments and projects. (10%)
• Train and supervise colleagues across other groups on experimental techniques and procedures offered by Immunological Toolbox. (5%)
• Participate in lab management including equipment maintenance, inventory management, and adherence to safety protocols. (5%)

Research communication and collaboration

• Communicate research progress and findings through regular team meetings and reports.
• Prepare high-quality manuscripts for publication in peer-reviewed journals.
• Present research findings at national and international scientific conferences.
• Ensure compliance with health, safety, and biosecurity regulations to maintain a safe and effective working environment.

Contributing to the wider research community

• Engage in interdisciplinary collaborations within The Pirbright Institute and with external partners.
• Serve on relevant committees and participate in outreach and public engagement activities.
• Support the broader scientific mission of the Institute by contributing to strategic research initiatives and funding proposals.
                              

Due to the nature of the work we do, all successful applicants will be required to go through a comprehensive screening process including reference and qualification checks, financial and security clearances.

Essential/Desirable requirements

Essential

• PhD (or equivalent experience) in immunology, molecular biology, or a related bioscience field.
• A broad understanding of immunology and antigen receptors.
• Proficiency in designing assays with a keen attention to detail, ensuring the inclusion of appropriate controls to validate experimental results.
• Strong background in antibody biology, B cell immunology, and antigen recognition.
• Hands-on experience with antibody discovery techniques, including flow cytometry and molecular cloning.
• Strong communication 

Desirable

• Experience in recombinant antibody production and high-throughput expression systems.
• Knowledge of next-generation sequencing (NGS) techniques for antibody discovery.
• Expertise in functional assays, including ELISA, ELISpot, ADCC, and ADCP.
• A strong publication record in immunology, molecular biology, or related disciplines.

What we offer

• Generous Group Personal Pension Scheme and life cover (subject to age and earnings)
• 25 days annual leave per annum, pro rata, plus 10.5 public and privilege days
• Buy and sell annual leave
• Option to carry over up to two weeks annual leave
• Pirbright gym with subsidised membership
• Pirbright social club
• Pirbright Lifestyle Hub (employee discount site)
• Cycle to work
• Subsidised employee restaurant
• Childcare allowance
• Free onsite parking
• Electric car charging facilities 

Due to the high volume of applications we receive, if you have not heard from us within one month from closing date of the vacancy, then please contact us on jobs@pirbright.ac.uk for an update.